Is Delta Plus Why UK Covid Cases Are So High Compared To Europe?


 
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By Yueqi Yang

Cases spread rapidly in schools as U.K. vaccination drive lags. Daily new cases are running at highest levels since mid-July.

Surging Covid cases in the U.K. have left the country behind the rest of Europe with former U.S. Food and Drug Administration Commissioner Scott Gottlieb calling for urgent research into a mutation known as delta plus.

Britain, faster to reopen and relax restrictions than other European countries, reported the highest daily jump in new cases on Sunday since mid-July. Weekly deaths from the virus topped 800 for each of the past six weeks, higher than in other major western European nations.

The U.K. also has lagged in rolling out the vaccines to adolescents amid concerns that some side effects undermined the net benefit of the shots given children are less likely to become seriously ill. The delay meant most older children weren’t offered a vaccine until the school year had started, and they’re now seeing the highest levels of infection in the population.

Prevalence of Covid-19 is growing among those aged 17 and younger, the latest React-1 study led by Imperial College London found last week. The reproduction rate in that age group was 1.18, meaning that on average every 10 young people infected are passing it on to about 12 others.

The delta plus strain Gottlieb highlighted includes the K417N mutation, which has stoked concern because it’s also harbored by the beta variant that’s associated with an increased risk of reinfection.

“We need urgent research to figure out if this delta plus is more transmissible, has partial immune evasion,” he said in a tweet. “There’s no clear indication that it’s considerably more transmissible, but we should work to more quickly characterize these and other new variants.”

"UK reported its biggest one-day Covid case increase in 3 months just as the new delta variant AY.4 with the S:Y145H mutation in the spike reaches 8% of UK sequenced cases. We need urgent research to figure out if this delta plus is more transmissible, has partial immune evasion?"— Scott Gottlieb, MD (@ScottGottliebMD) October 17, 2021.

U.K. researchers said in late June that there’s no evidence yet to suggest the additional mutation is more worrisome. A German paper out earlier this month found while both delta and delta plus infect lung cells more efficiently than the original coronavirus strain, delta plus doesn’t appear to be significantly more dangerous than delta.

Gottlieb, who serves on Pfizer’s board of directors, led the FDA from 2017 to 2019. He has been promoting his new book, “Uncontrolled Spread: Why Covid-19 Crushed Us and How We Can Defeat the Next Pandemic.”

In England, the percentage of people testing positive continued to increase in the week ending Oct. 9, with an estimated 890,000 people having Covid-19, or about 1 in 60, according to the Office for National Statistics.

The percentage of people testing positive from Aug. 29 through Oct. 9 was highest among those in school years seven to 11, which corresponds roughly to ages 11 through 15, according to the ONS. More than 8% of people in that age group tested positive in the period, compared with only 0.6% for those ages 25-34.

To date, the U.K. has recorded almost 140,000 Covid-related fatalities.

“At the moment the U.K. has a higher level of Covid-19 than most other comparable countries, this is seen not just in positive tests but in hospital admissions and deaths,” Jim Naismith, a professor at the University of Oxford, wrote in a statement published by the Science Media Centre Oct. 15. Each death “represents a tragedy,” he said.


 
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